Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology

Barroroh, Himmatul and Dewi, Ayu Fitriana and Hasanah, Hafidatul and Akyunul, Akyunul (2020) Short-term Momordica charantia L. Fruit Concentrated Infusions Therapy on Alloxan-Induced Rattus norvegicus Kidney Glomerulus Cells Histology. In: ICONQUHAS 2018, 2-4 October 2018, Bandung, Indonesia.

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Abstract

The aim of this research is to know the effect of short-term bitter melon (Momordica Charantia L.) fruit concentrated infusions therapy on the histology of alloxan-induced rat kidney glomerulus. Renal glomerular histology was observed using Hematoxylin-Eosin (HE) test. A therapeutic dose of bitter melon fruit concentrated therapy used was 0.15 mL/200 g BW; 0.30 mL/200 g BW; 0.45 mL/200 g BW; 0.60 mL/200 g BW; 0.80 mL/200 g BW and 1 mL/200 g BW. The results showed that the bitter melon fruit concentrated infusions therapy on alloxan-induced DM rats was able to decrease the Blood Glucose Levels (BGL) of the treated rats in varying degrees. The therapy also successfully repairs the damage kidney glomerulus cells of all rats treated with an average bowman's space improvement of 110% of healthy rat's kidney glomerulus cells. It appears that the mechanism of the bitter melon active substance in reducing the BGL occurs through a different path to its mechanism in repairing damaged glomerulus cells.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: diabetes mellitus; extract; bitter melon; momordica; hematoxylin; eosin; he; therapy; blood glucose levels; natural product; alloxan; kidney
Subjects: H Social Sciences > H Social Sciences (General)
Depositing User: EAI Editor IV
Date Deposited: 12 Jul 2021 12:48
Last Modified: 12 Jul 2021 12:48
URI: https://eprints.eudl.eu/id/eprint/4579

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