Proceedings of the 3rd International Conference on Environmental Risks and Public Health, ICER-PH 2018, 26-27, October 2018, Makassar, Indonesia

Research Article

The Effect of Curcuma Zedoaria (Berg.) Roscoe Extract on Liver Function Tests of Rattus norvergicus Exposure by Cigarette Smoke

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  • @INPROCEEDINGS{10.4108/eai.26-10-2018.2288699,
        author={Sudir  Sumarheni and Nursyamsi  Nursyamsi and Rina  Agustina and Fitriyani  Fitriyani and Fauziah  Amin and Rahmawati  Faisal and Sartini  Sartini},
        title={The Effect of Curcuma Zedoaria (Berg.) Roscoe Extract on Liver Function Tests of Rattus norvergicus Exposure by Cigarette Smoke},
        proceedings={Proceedings of the 3rd International Conference on Environmental Risks and Public Health, ICER-PH 2018, 26-27, October 2018, Makassar, Indonesia},
        publisher={EAI},
        proceedings_a={ICER-PH},
        year={2019},
        month={11},
        keywords={curcuma zedoaria cigarette},
        doi={10.4108/eai.26-10-2018.2288699}
    }
    
  • Sudir Sumarheni
    Nursyamsi Nursyamsi
    Rina Agustina
    Fitriyani Fitriyani
    Fauziah Amin
    Rahmawati Faisal
    Sartini Sartini
    Year: 2019
    The Effect of Curcuma Zedoaria (Berg.) Roscoe Extract on Liver Function Tests of Rattus norvergicus Exposure by Cigarette Smoke
    ICER-PH
    EAI
    DOI: 10.4108/eai.26-10-2018.2288699
Sudir Sumarheni1,*, Nursyamsi Nursyamsi2, Rina Agustina1, Fitriyani Fitriyani1, Fauziah Amin1, Rahmawati Faisal1, Sartini Sartini1
  • 1: Faculty of Pharmacy, Hasanuddin University, Makassar
  • 2: Faculty of Medicine, Hasanuddin University
*Contact email: sumarheni@unhas.ac.id

Abstract

Curcuma zedoaria (Berg.) Roscoe has been widely used traditionally as a valuable medicinal plant to treat many diseases due to its activity on repairing cell damage. This study aimed to evaluate the effect of ethanol extract of Curcuma zedoaria (CZE) on liver function test levels in male Winstar rats exposed by cigarette smoke. A total of 30 male rats were divided into six groups (n=5), i.e., control group(G1); negative control(G2); positive control(G3); cigarette smoke-exposure followed by administration of CZE 350 mg/kg b.wt group(G4), cigarette smoke-exposure followed by administration of CZE 525 mg/kg b.wt group(G5), and administration of CZE 525 mg/kg b.wt group (G6). Treatments were given for 45 days before blood collection and MDA measurements on rat liver tissue. The results showed that administration of 350 mg/kg b.wt., and 525 mg/kg b.wt reduced total protein, ALT, AST and ALP levels on rat exposed by cigarette smoke as well as decreased liver peroxidase level based on the average profile of MDA on rat liver tissue. In conclusion, administration of CZE showed the hepatoprotective effect on rats exposed by cigarette smoke.