Description of Insulin Resistance and Beta-Cell Pancreas Dysfunction in Prediabetic Patients

Decroli, Eva and Efendi, Yanne Pradwi and Kam, Alexander and Manaf, Asman and Syahbuddin, Syafril (2019) Description of Insulin Resistance and Beta-Cell Pancreas Dysfunction in Prediabetic Patients. In: ICOMHER 2021, 13-14 November 2018, Padang, West Sumatera, Indonesia.

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Prediabetes is the forerunner of diabetes mellitus. Hence it has to be carefully cared for. Main conditions causing this are insulin resistance and beta cell dysfunction. Insulin resistance can be assessed by using several methods, one of which is performed by assessing the value of HOMA-IR. Beta cell function can be determined by assessing HOMA-B. In this research we aim to obtain the description of insulin resistance and beta cell pancreas dysfunction on prediabetic patients, using the analytic observational method with cross-sectional approach. HOMA-IR and HOMA-B were assessed in 20 prediabetic patients, and their values were obtained by examining basal insulin and fasting glucose level. We found man to woman ratio 1:1, with mean (SD) age 35.8 (5.7) years old, BMI 24.9 (4.3) kg/m2, fasting blood glucose 104.8 (4.3) mg/dL, and blood glucose two hours after oral glucose tolerance test 121.7 (23.1) mg/dl. Mean of HOMA-IR on prediabetic patients was 4.1 (3.2) and mean of HOMA-B was 188.3 (155.1). The increase of insulin resistance on this study is by studies that were conducted by Nguyen and Mohtarin. The increase of HOMA-B in this study is following other studies by Mohtarin and Owei, supposedly due to beta cell compensation process against the increase of insulin resistance. We conclude that the increase of HOMA-IR in prediabetics is compensated for by an increase in HOMA-B.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: prediabetes homa ir homa b
Subjects: R Medicine > R Medicine (General)
Depositing User: EAI Editor IV
Date Deposited: 28 Oct 2021 08:20
Last Modified: 28 Oct 2021 08:20

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