The Correlation between Old-Generation Antiepileptic Drugs Usage with Carotid Intima-Media Thickness in Epilepsy Patient

Permana, Hendra and Sutia, Dedi and Susanti, Restu and Khair, Umul (2019) The Correlation between Old-Generation Antiepileptic Drugs Usage with Carotid Intima-Media Thickness in Epilepsy Patient. In: ICOMHER 2021, 13-14 November 2018, Padang, West Sumatera, Indonesia.

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Abstract

Epilepsy is one of the neurological disorders that quite common, which about 50 million people worldwide affected each year. Most of the epilepsy patients need long-term therapy, and old-generation of antiepileptic is often used as monotherapy. The incidence of atherosclerosis can be estimated by the thickness of tunica intima-media carotid artery. This study aimed to evaluate the correlation between long-term usage of old-generation antiepileptic drugs and the carotid intima-media thickness. We conducted a cross-sectional study in DR. M. Djamil Hospital, Padang, between March until August 2018. A total of 26 epilepsy patients were recruited. Those with the cardiovascular risk factor, the subject who did not undergo treatment regulary were excluded. The carotid intima-media thickness was measured by EPIQ7 Ultrasound systems Machine. The relationship between variables was analyzed using Kendall’s tau test b, and p-value <0.05 was considered to be statistically significant. Most subjects received phenytoin as their regular AED (76.92%), while 4 subjects received Carbamazepine (15.38%) and 1 subject received phenobarbital (3.84%), and the other drugs (3.84%). The mean duration of therapy was 2.88 years. There is no correlation between long-term usage of AEDs and carotid intima-media thickness in epileptic patients (p=0.052). There was no significant correlation between long-term old-generation usage of antiepileptic drug and carotid intima-media thickness

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: antiepileptic drug carotid intima-media thickness epilepsy old generation
Subjects: R Medicine > R Medicine (General)
Depositing User: EAI Editor IV
Date Deposited: 28 Oct 2021 08:20
Last Modified: 28 Oct 2021 08:20
URI: https://eprints.eudl.eu/id/eprint/7742

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