Analysis of Neuron-Specific Enolase of Cerebrospinal Fluid and Post Mortem Serum of Blunt Head Trauma in Cause and Time of Death Determination

Susanti, Rika and Hidayat, Taufik (2019) Analysis of Neuron-Specific Enolase of Cerebrospinal Fluid and Post Mortem Serum of Blunt Head Trauma in Cause and Time of Death Determination. In: ICOMHER 2021, 13-14 November 2018, Padang, West Sumatera, Indonesia.

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Abstract

Blunt head trauma is the highest cause of death in criminal crime. Various attempts have been conducted to find alternative substitutes for the autopsy to determine the cause of death. NSE levels have been used as biomarkers in blunt head trauma in a living patient. The purpose of this study was to analyze NSE levels of CSF and serum in cause and time of death determination. This study was an experimental study with a post-test only group design, with the treatment of death due to blunt head trauma compared to deaths from acute ketamine poisoning. The number of treatment groups was 8, with samples of each group were 6 adult Sprague Dawley Rattus novergicus. NSE levels were examined at 0 hours, 1 hour, 2 hours and 3 hours after death. Analysis of NSE levels of CSF and serum in determining the cause and time of death was undertaken with the General Linear Model Repeated Measure test. We found increases in NSE levels of CSF and serum in both groups of deaths due to blunt head trauma and acute ketamine poisoning, and there was a significant difference between the two groups with p = 0.005 of serum NSE levels. There was no significant difference in the time of death between NSE levels of CSF and serum. Overall, there are increases in NSE levels of CSF and serum in deaths due to blunt head trauma and acute ketamine poisoning

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: blunt head trauma nse cause of death time of death determination
Subjects: R Medicine > R Medicine (General)
Depositing User: EAI Editor IV
Date Deposited: 28 Oct 2021 10:52
Last Modified: 28 Oct 2021 10:52
URI: https://eprints.eudl.eu/id/eprint/7773

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