SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy

Anum, Qaira and Darwin, Eryati and Linuwih, Sri and Tjong, Djong Hon (2019) SNP PARK2-e01 (-2599) Polymorphism PARK2 Gene As A Risk Factor Caused Leprosy. In: ICOMHER 2021, 13-14 November 2018, Padang, West Sumatera, Indonesia.

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Abstract

Genetic factor is important in determining a person to get leprosy. Genes that affect susceptibility to Mycobacterium Leprae are SNP PARK2-e01 (-2599) PARK2 genes. These genes act as phagocytosis in macrophages in a non-specific immune process. This study aims to prove that there are SNP PARK2-e01 (-2599) PARK2 genes in leprosy and household contact patients. SNP PARK2-e01 (-2599) PARK2 genes were analyzed in 60 individual with leprosy or household contact from West Sumatera. The purpose of this study was to prove the SNP PARK2-e01(-2599) PARK2 gene in leprosy and household contact patients. This research method is observational research with cross-sectional comparative study design, by comparing SNP PARK2-e01 (-2599). The results of this study obtained the most aged in leprosy patients was 12-16 years and household contact aged was 36-45 years (p = 0.293). The leprosy patients group who had SNP PARK2-e01 (-2599) polymorphism PARK2 gene was 90% while in household contact was 83.3%. Statistical test results obtained p = 0.75 with OR = 1.8 (95% CI 0.389-8.323). The conclusion proved he was an SNP PARK2-e01 (-2599) PARK2 gene in leprosy and household contact patients

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: leprosy polymorphism park2 gen snp park2-e01 (-2599)
Subjects: R Medicine > R Medicine (General)
Depositing User: EAI Editor IV
Date Deposited: 28 Oct 2021 10:52
Last Modified: 28 Oct 2021 10:52
URI: https://eprints.eudl.eu/id/eprint/7778

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