Correlation of Inflammation Mediator Profile Expression Between Tissues and Mucosal in Chronic Rhinosinusitis with Nasal Polyp

Huriyati, Effy (2019) Correlation of Inflammation Mediator Profile Expression Between Tissues and Mucosal in Chronic Rhinosinusitis with Nasal Polyp. In: ICOMHER 2021, 13-14 November 2018, Padang, West Sumatera, Indonesia.

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Abstract

There are differences inflammatory patterns in Chronic Rhinosinusitis with Nasal Polyp (CRSwNP) between Caucasians and Asians. One of the most convenient and non-invasive examination tools to find out the inflammatory pattern of CRSwNP is such as mucosal brushing of the polyp. This research investigated the correlation of expression IL-5, IL-8, and IL-17A between the tissue and mucosal polyp.A cross-sectional comparative study involving 15 samples of mucosal brushing and 15 of polyp tissues were performed. We measured IL-5, IL-8, and IL-17A level of mucosal brushing with the Enzyme-Linked Immunosorbent Assay (ELISA) and polyp tissues with immunohistochemistry (IHC) examination. The mean expression of IL-5, IL-8, and IL-17A by IHC was 62.07% (26.294), 87.33% (16.969), 88.20% (16.781) and ELISA was 0.86 (0.13), 1930.60 (879.83), 25.60 (16.969). There was no significant relationship between tissue (IHC) and mucosa (ELISA) (p> 0.05), but in IL-5 expression there was a moderate positive correlation (0.41<r<0.60).The moderate positive correlation between mucosa and tissue polyp concludes that simple tests such as mucosal brushing can be used to see IL-5 expression in CRSwNP. However, IHC and ELISA tests on IL-8 and IL-17A had negative correlation because there is a variability inflammatory expression between mucosal dan tissues. Mucosal brushing can be used as a simple and non-invasive examination to see IL-5 expression in CRSwNP

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: chronic rhinosinusitis with nasal polyps interleukin-5 interleukin-8 interleukin-17a
Subjects: R Medicine > R Medicine (General)
Depositing User: EAI Editor IV
Date Deposited: 28 Oct 2021 10:54
Last Modified: 28 Oct 2021 10:54
URI: https://eprints.eudl.eu/id/eprint/7797

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