The Effects of Oral Supplementation of Bitter Melon (Momordica charantia L.) Leaves Extract on the VEGF Serum Level in Diabetic Foot Ulcers: Randomized Controlled Trial

Rosyid, Fahrun Nur and Prasetyo, Tomy Adi and Muhtadi, Muhtadi and HS, K Heri Nugroho (2021) The Effects of Oral Supplementation of Bitter Melon (Momordica charantia L.) Leaves Extract on the VEGF Serum Level in Diabetic Foot Ulcers: Randomized Controlled Trial. In: BIS-HSS 2020, 18 November 2020, Magelang, Central Java, Indonesia.

[thumbnail of PDF]
Preview
Text (PDF)
eai.18-11-2020.2311791.pdf - Published Version

Download (226kB) | Preview

Abstract

The purpose of this study is to determine the effect of oral Bitter Melon (Momordica charantia L.) leaves extract on the serum VEGF level in diabetic foot ulcers. The trial was randomized, double-blinded, and placebo-controlled. Thirty diabetic foot ulcer (DFU) patients with a PEDIS score of 1-8 who met the criteria were divided into two groups: The treatment group received the bitter melon leaves extract orally at a dose of 6 g/day, while the control group received a placebo. The intervention lasted four weeks, and baseline and end-of-treatment VEGF serum levels were determined. The paired t-test and independent t-test were used to analyze the data. After four weeks of treatment, the baseline VEGF serum level in the treatment group decreases from 431.5248.5 to 236.9158 pg/ml (the decline begins at 194.5197.9 pg/ml). Meanwhile, in the control group, the concentration decreases from 382.4351,4 to 191.6121.9 pg/ml (the concentration decreases to 190.8324.9 pg/ml). The effect of oral supplementation with Bitter Melon leaves extract on VEFG serum levels was found to be insignificant (p=0.39). Oral bitter melon leaf extract supplementation was not shown to increase VEFG serum levels in DFU patients.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: bitter melon momordica charantia l vegf diabetes mellitus diabetic foot ulcer
Subjects: H Social Sciences > H Social Sciences (General)
Depositing User: EAI Editor IV
Date Deposited: 13 Apr 2022 08:22
Last Modified: 13 Apr 2022 08:22
URI: https://eprints.eudl.eu/id/eprint/10469

Actions (login required)

View Item
View Item