Research Article
Comparison of toxic effects of some nonsteroidal anti-inflammatory medications on the kidney and lung tissues of rats
@INPROCEEDINGS{10.4108/eai.7-9-2021.2314408, author={Manal N. Al-Hayder and Tamadir H. W. Aledani and Rafid A. Doulab}, title={Comparison of toxic effects of some nonsteroidal anti-inflammatory medications on the kidney and lung tissues of rats}, proceedings={Proceedings of 2nd International Multi-Disciplinary Conference Theme: Integrated Sciences and Technologies, IMDC-IST 2021, 7-9 September 2021, Sakarya, Turkey}, publisher={EAI}, proceedings_a={IMDC-IST}, year={2022}, month={1}, keywords={blood parameters histopathology nonsteroidal anti-inflammatory drugs toxic effects}, doi={10.4108/eai.7-9-2021.2314408} }- Manal N. Al-Hayder
Tamadir H. W. Aledani
Rafid A. Doulab
Year: 2022
Comparison of toxic effects of some nonsteroidal anti-inflammatory medications on the kidney and lung tissues of rats
IMDC-IST
EAI
DOI: 10.4108/eai.7-9-2021.2314408
Abstract
Nonsteroidal anti-inflammatory drugs that include diclofenac sodium and naproxen are frequently and widely used. Nevertheless, they cause adverse deleterious effects on multiple organs. This work represents a comparative study of the toxic effects of diclofenac sodium and naproxen in rats that is almost nonexistent.The methodology is applied on 15 rats orally administered nonsteroidal drugs for three weeks. The hematopathological and histopathological effects were evaluated. Abnormal hematological profile in both diclofenac sodium and naproxen treated groups comparing to the control is illustrated. Interestingly, the statistical comparison between the two treated groups revealed that in the naproxen group the red blood cells count, hemoglobin, and mean corpuscular hemoglobin concentration were significantly lower, while the platelets and plateletcrit significantly increased more than another group. The histopathological micrographs demonstrated the harmful effects of both drugs in the kidney and lung tissues. We concluded that a high dose of naproxen potentially generates higher toxic effects compared to a lower dose of diclofenac sodium as habitually used.