Ameliorating effect of Alteplase in bleomycin-induced pulmonary fibrosis in adult rats

Thuwaini, Mahdi M. (2022) Ameliorating effect of Alteplase in bleomycin-induced pulmonary fibrosis in adult rats. In: IMDC-IST 2021, 7-9 September 2021, Sakarya, Turkey.

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Abstract

The current research was designed to investigate the ameliorating effect of alteplase in bleomycin-induced pulmonary fibrosis in adult rats. Alteplase 0.9mg/ kg i.p. as a single dose daily for 3weeks, significantly ameliorated the declined serum levels of SOD and GSHpx, and significantly, decrease the elevated level of hydroxyproline in (BLM) treated rats. Sections of lung of BLM treated rats showed extensive damage of the lung tissue with loss of the normal alveolar architecture and the majority of the alveolar walls were occupied by collagenous fibers with diffuse cellular infiltration, with bands of collagen fibers, and an increased macrophages and fibroblast cells. Regard the lung of rats treated by alteplase in combination with (BLM) revealed that fibrotic lesions appeared less, with mild inflammatory cells, minimum blood vessels congestion and most parenchyma tissue appeared similar to normal structure. Therefore, the findings may be offer one of therapeutic strategy to prevent the lung fibrosis associated with anticancer therapy.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: alteplase bleomycin pulmonary fibrosis rats gsh sod hyp
Subjects: T Technology > T Technology (General)
Depositing User: EAI Editor IV
Date Deposited: 27 Apr 2022 13:23
Last Modified: 27 Apr 2022 13:23
URI: https://eprints.eudl.eu/id/eprint/10866

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