Research Article
Clinical Significance of Some Tumour Biomarkers in the Diagnosis of Breast Cancer in Comparison with Histopathological Biopsy
@INPROCEEDINGS{10.4108/eai.7-9-2021.2314939, author={Adil Nadhim Radhi and Mahdi Murshd Thuwaini and Hamed Jaddoa Abbas}, title={Clinical Significance of Some Tumour Biomarkers in the Diagnosis of Breast Cancer in Comparison with Histopathological Biopsy}, proceedings={Proceedings of 2nd International Multi-Disciplinary Conference Theme: Integrated Sciences and Technologies, IMDC-IST 2021, 7-9 September 2021, Sakarya, Turkey}, publisher={EAI}, proceedings_a={IMDC-IST}, year={2022}, month={1}, keywords={breast cancer tumour markers ca 15-3 ca 2729 ca 549}, doi={10.4108/eai.7-9-2021.2314939} }- Adil Nadhim Radhi
Mahdi Murshd Thuwaini
Hamed Jaddoa Abbas
Year: 2022
Clinical Significance of Some Tumour Biomarkers in the Diagnosis of Breast Cancer in Comparison with Histopathological Biopsy
IMDC-IST
EAI
DOI: 10.4108/eai.7-9-2021.2314939
Abstract
This study aimed to assess the diagnostic power of tumour biomarkers (Serum CA15-3, CA27.29, and CA549) in the diagnosis or confirming the diagnosis of breast cancer (BC) in comparison with histopathological biopsy. A case-control study consisted of (60) female patients with breast cancer and (30) healthy subjects as control. Kits were used to measure serum CA15-3, while Enzyme-Linked Immunosorbent Assay (ELISA) was used to measure Serum CA27.29 and CA549. The current study showed that there were highly significant increases in the levels of CA15-3, CA27-29, BC patients compared to the control group. There was also a highly significant increase in the levels of CA15-3, CA27-29, in BC patients with stage IV compared to another state. The study also showed that the sensitivity values of the markers were: 87%, 36%, 56% for the markers CA15-3, CA27-29, and CA 549 respectively. The study also reveals that specificity values of the markers were: 62%, 36%, 40% for the same markers respectively. It could be concluded these markers could be used in the diagnosis of breast cancer.