Influence of Genetic polymorphism of IL-2 and IL-6 on susceptibility to Helicobacter pylori infection and prognosis of Gastroduodenal Diseases

We aimed to study the association of IL-6 -174G/C, -572G/C, and IL-2 −330T/G and +114T/G polymorphisms with the pathogenesis of H. pylori infections. PCR, DNA sequencing, and ELISA technique were used to characterize the IL-2 and IL-6 polymorphisms and to measure their serum levels in 24 H. pylori-positive patients (5 chronic gastritis, 17 peptic ulcer, 2 gastric cancer) and 13 healthy people. IL-6 -174GG genotype was the most frequent (75%) among patients at higher risk of gastric cancer (OR: 4.8, P <0.05). A high prevalence of IL-6-572GG genotype (66.7%) was observed among patients with a possible risk of gastric cancer in subjects carrying GC genotype (OR: 2.7, P >0.05). IL-2 -330TT and +114TG genotypes were most frequent (58.3%, 50% respectively) among patients, with a possible risk of gastric cancer in patients carrying IL-2-330GG (OR: 2.4) and IL-2+114TT genotype (OR: 2.26). The serum levels of ILs -2/6 were varied about genetic variation.