Research Article
Comparison of Plateletic Reactivity Affects Between Ticagrelor and Clopidogrel in Acute Myocardial Infarction Patients which Drive Coroner Intervention
@INPROCEEDINGS{10.4108/eai.13-11-2018.2283590, author={Elly Usman and Muhammad Fadil and Gestina Aliska and Firdawati Firdawati}, title={Comparison of Plateletic Reactivity Affects Between Ticagrelor and Clopidogrel in Acute Myocardial Infarction Patients which Drive Coroner Intervention}, proceedings={Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia}, publisher={EAI}, proceedings_a={ICOMHER}, year={2019}, month={5}, keywords={clopidogrel acute myocardial infarction ticagrelor}, doi={10.4108/eai.13-11-2018.2283590} }- Elly Usman
Muhammad Fadil
Gestina Aliska
Firdawati Firdawati
Year: 2019
Comparison of Plateletic Reactivity Affects Between Ticagrelor and Clopidogrel in Acute Myocardial Infarction Patients which Drive Coroner Intervention
ICOMHER
EAI
DOI: 10.4108/eai.13-11-2018.2283590
Abstract
This study aimed to determine the effect of P2Y12 inhibition by ticagrelor and clopidogrel and its effect on Major Adverse Cardiovascular Events (MACE) of patients with Acute Myocardial Infarction who underwent Percutaneous Coronary Intervention at Dr. M. Djamil General Hospital Padang. The design in this study was a quasi-experimental. The study was conducted at Dr. M. Djamil General Hospital Padang and the Department of Pharmacology and Therapeutics Faculty of Medicine Universitas Andalas in August - December 2016. The population in this study were acute coronary syndrome patients who were treated in the Department of Cardiology of Dr. M. Djamil General Hospital Padang and underwent Percutaneous Coronary Intervention. The relationship between the Platelet Reaction Unit (PRU) value above or below the cut-off with the occurrence of MACE through the chi-square test. A two-tailed P-value of <0.05 was considered statistically significant. Data analysis was carried out in Stata version 14.2 (Stata Corporation). The results showed that administration of antiplatelet with clopidogrel obtained non-responsive platelet reaction unit (PRU) of 33.3% and hyperresponsiveness of 66.7% whereas in non-responsive ticagrelol found non-responsive PRU and experienced 100% hyperresponsiveness. PRU with clopidogrel 128.1 ± 99.6 and ticagrelol 21.6 ± 34.59. There are differences in PRU with clopidogrel and ticagrelol in patients with Acute Myocardial Infarction